Commonly Used H1 and H2 Histamine Receptor (HR) Blockers Decrease Cholangiocarcinoma Xenograft Tumor Growth, Angiogenesis and EMT
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Action of histamine and H1 and H2 blockers on the cardiopulmonary circulation.
Systemic and pulmonary hemodynamic responses to histamine were investigated inchronically instrumented unanesthetized nonpregnant ewes. Histamine was administered intravenously and into the pulmonary artery. The effects of the same doses of histamine were assessed following H1 and H2 receptor blockade. The effects ocular changes were also monitored. Results indicate that intravenous histamine p...
متن کاملEffects of intracerebroventricular injection of histamine and H1, H2 receptor antagonists on electrocardiographic parameters in broiler chickens
The aim of this study was to assess the effects of exogenous histamine and H1 and H2 central receptorson electrocardiographic (ECG) parameters, heart rate and mean electrical axis in broiler chickens. For thispurpose, Ross broiler chickens (750-800 g weight) received intracerebroventricularly (ICV) histamine.Moreover, to determine the receptors involved in histamine-induced alterations in ECG c...
متن کاملConjunctival eosinophil infiltration evoked by histamine and immediate hypersensitivity. Modification by H1- and H2-receptor blockade.
The present histological studies have demonstrated that histamine causes dose-dependent eosinophil infiltration into the conjunctiva. A highly directional movement toward the conjunctival epithelium was observed, and the presence of large numbers of degranulating eosinophils appeared to result in epithelial cell damage and goblet cell discharge. Blockade of H2-receptors by systemic cimetidine p...
متن کاملOpposite functions of histamine H1 and H2 receptors and H3 receptor in substantia nigra pars reticulata.
The substantia nigra pars reticulata (SNr) is a key basal ganglia output nucleus. Inhibitory outputs from SNr are encoded in spike frequency and pattern of the inhibitory SNr projection neurons. SNr output intensity and pattern are often abnormal in movement disorders of basal ganglia origin. In Parkinson's disease, histamine innervation and histamine H3 receptor expression in SNr may be increa...
متن کاملHistamine H2 receptor trafficking: role of arrestin, dynamin, and clathrin in histamine H2 receptor internalization.
Agonist-induced internalization of G protein-coupled receptors (GPCRs) has been implicated in receptor desensitization, resensitization, and down-regulation. In the present study, we sought to establish whether the histamine H2 receptor (H2r) agonist amthamine, besides promoting receptor desensitization, induced H2r internalization. We further studied the mechanisms involved and its potential r...
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ژورنال
عنوان ژورنال: Gastroenterology
سال: 2017
ISSN: 0016-5085
DOI: 10.1016/s0016-5085(17)33944-6